AHU-377 hemicalcium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AHU-377 hemicalcium salt是一种 AHU-377的半钙盐形式,是脑啡肽酶的抑制剂,IC50值为5 nM[1].
AHU-377和血管紧张素II AT1受体拮抗剂缬沙坦(valsartan)以摩尔比1:1组成LCZ696.LCZ696是一种血管紧张素受体脑啡肽酶抑制剂.它可降低血压,是治疗心力衰竭的潜在新药.AHU-377是前体药物,可以通过酶裂解乙酯基转换成活性形式LBQ657.据报道,在DAHI-SS大鼠中,AHU-377(30 mg/kg和100 mg/kg,PO)可以剂量依赖的方式引起降压作用.但在DOCA盐高血压大鼠中,降压效果较弱[2,3].
参考文献：
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacology 2011, 11(Suppl 1):P33.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 430.52 |
| Cas No. | 1369773-39-6 |
| Formula | C24H28Ca0·5NO5 |
| Solubility | ≥17.9 mg/mL in DMSO; ≥2.43 mg/mL in EtOH with gentle warming and ultrasonic; ≥3.3 mg/mL in H2O with gentle warming and ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | O=C(OCC)[C@@H](C)C[C@@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[0.5Ca2+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
