AGN 192403 hydrochloride
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
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Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
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Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
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Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AGN 192403 hydrochloride是一种选择性的咪唑啉1受体的配体[1].
咪唑啉受体是可乐定和其他咪唑啉的主要受体.咪唑啉1受体(I1受体)通过咪唑啉抑制交感神经行为,从而降低血压.
AGN 192403 hydrochloride是一种选择性的I1受体的配体.AGN192403表现出对I1受体的亲和力,Ki值为42 nM,比可乐定效力仅低5倍.然而,AGN192403没有激动剂和拮抗剂活性.在猴子和大鼠中,AGN192403(5000 μg/kg)对血压没有影响[1].在星形胶质细胞中,AGN 192403抑制细胞色素c释放\溶酶体吖啶橙再定位\caspase-9的激活和线粒体膜电位的降低\萘醌诱导的细胞毒性.此外,AGN 192403抑制抗霉素A\鱼藤酮和线粒体呼吸抑制剂诱导的线粒体功能障碍和细胞毒性[2].在离体正常血压大鼠心脏中,AGN192403抑制moxonidine(10-6 M)诱导的心房利钠肽(ANP)的释放[3].
参考文献:
[1] unk SA1, Lai RK, Burke JE,Munk SA1, Lai RK, Burke JE,Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2. 2.1]heptane: a potent imidazoline1 receptor specific agent.Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193. PMID: 8632424.Stephen A. Munk,* Ronald K. Lai, James E. Burke, [1]. Munk SA, Lai RK, Burke JE, et al. Synthesis and Pharmacologic Evaluation of 2-endo-Amino-3-exoisopropylbicyclo[2.2.1]heptane: A Potent Imidazoline1 Receptor Specific Agent. J Med Chem, 1996, 39(6): 1193-1195.
[2]. Choi DH, Kim DH, Park YG, et al. Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med, 2002, 33(10): 1321-1333.
[3]. Mukaddam-Daher S, Menaouar A, Gutkowska J. Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts. Eur J Pharmacol, 2006, 541(1-2): 73-79.
Physical Appearance | White solid |
Storage | Store at RT |
M.Wt | 189.73 |
Cas No. | 1021868-90-5 |
Formula | C10H19N·HCl |
Solubility | Soluble to 100 mM in H2O |
Chemical Name | (1R,2R,3R,4S)-3-isopropylbicyclo[2.2.1]heptan-2-amine hydrochloride |
SDF | Download SDF |
Canonical SMILES | CC([C@]1([H])[C@@]2([H])CC[C@]([C@@]1([H])N)([H])C2)C.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
化学结构
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