Aclacinomycin A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Aclacinomycin A(阿克拉霉素A)是拓扑异构酶I和II的双重抑制剂[1]。
阿克拉霉素A是一种抗癌药物,可很大程度的降低肿瘤对正常细胞的损害。阿克拉霉素A对多种实体肿瘤和血液系统恶性肿瘤都有一定的疗效。对A549、HepG2和MCF-7细胞具有一定的细胞毒性,IC50分别为0.27μM、0.32μM和0.62μM。阿克拉霉素A可以诱导细胞凋亡,随着孵育时间延长,凋亡效应可以演变为坏死。有报道称,阿克拉霉素A 可以增加caspase-3和caspase-8的活性,从而诱导PARP的激活。除此之外,阿克拉霉素A可以作为opoisomerases的抑制剂,在V79和IRS-2细胞中引起DNA损伤。通过抑制topo II,阿克拉霉素A用于治疗急性白血病、淋巴瘤和其它实体瘤[1,2]。
参考文献:
[1] Hajji N, Mateos S, Pastor N, Domínguez I, Cortés F. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2;583(1):26-35.
[2] Rogalska A, Szwed M, Jó?wiak Z. Aclarubicin-induced apoptosis and necrosis in cells derived from human solid tumours. Mutat Res. 2010 Jul 19;700(1-2):1-10.
- 1. Terezie Hornofova, Alexandra Urbancokova, et al. "Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment." bioRxiv. August 06, 2023.
- 2. Venneker, S. "Exploiting vulnerabilities induced by recurrent mutations in chondrosarcoma and giant cell tumour of bone: therapeutic targeting of the altered epigenome and beyond." Leiden University Scholarly Publications. Jan 01, 2023.
- 3. Fenglin Wang, Min Xie, et al. "Homoharringtonine combined with cladribine and aclarubicin (HCA) in acute myeloid leukemia: A new regimen of conventional drugs and its mechanism." Oxid Med Cell Longev. 2022 Jul 13;2022:8212286. PMID: 35873796
Storage | Store at -20°C |
M.Wt | 811.87 |
Cas No. | 57576-44-0 |
Formula | C42H53NO15 |
Synonyms | Jaclacin,Aclarubicin,Aclarubicin A |
Solubility | Soluble in DMSO |
SDF | Download SDF |
Canonical SMILES | OC1=CC=CC(C(C2=C3C(O)=C4C([C@@H](C(OC)=O)[C@@](O)(CC)C[C@@H]4O[C@H]5C[C@H](N(C)C)[C@H](O[C@@H]6O[C@@H](C)[C@@H](O[C@@H]7O[C@@H](C)C(CC7)=O)[C@@H](O)C6)[C@H](C)O5)=C2)=O)=C1C3=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | 阿柔比星(阿克拉霉素A)是一种蒽环类药物,是20S蛋白酶体糜蛋白酶样活性的特异性抑制剂。 | |||||
靶点 | 20S proteasome | |||||
IC50 |