AC 261066
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AC 261066是视黄酸受体亚型β同工型2(RARβ2)的激动剂[1][2]。该物质也称作UVI2062[3]。AC 261066在大鼠中具有良好的口服生物利用度(Foral= 52%)[4]。AC 261066对AKR1B10的IC50值为51 ± 7 μM。在酶促试验中,AC 261066高达100 μM时对AKR1B1无抑制能力[3]。
视黄酸受体(RARs,亚型α、β、γ)与维甲酸X受体(RXR α、β、γ)形成二聚体复合物,编排复杂事件,如器官稳态、免疫功能、发育和繁殖[1]。RARβ2是视黄酸受体β亚型的同工体,其对视黄酸的亲和性和生物学功能与其他同工体不同[2]。
AC 261066不可诱导RPMI 8866 B细胞对ADAM28解聚素样结构域的细胞粘附,不可阻断atRA诱导的粘附[5]。
AC 261066治疗相比DMSO对照可显著抑制N. viridescens的尾部再生过程。当这些AC 261066处理的蝾螈在21天(分析时间)移除AC 261066,放回正常养殖水体,尾部再生开始。移除AC 26l066后五周,尾部完成再生。相比正常尾部再生,背腹图案发生了改变[6]。
参考文献:
[1]. Albane le Maire, Susana lvarez, Pattabhiraman Shankaranarayanan, et al. Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators. Current Topics in Medicinal Chemistry, 2012, 12: 505-527.
[2]. Christopher R. Gardner, Belamy B. Cheung, Jessica Koach, et al. Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy. Bioorg. Med. Chem., 2012, 20: 6877-6884.
[3]. Sergio Porté, Joan Giménez, Marta Dominguez, et al. Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity. Chemico-Biological Interactions, 2013, 202(1-3):186-94.
[4]. Birgitte W. Lund, Fabrice Piu, Natalie K. Gauthier, et al. Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist. J. Med. Chem., 2005, 48: 7517-7519.
[5]. Jarrett T. Whelan, Lei Wang, Jianming Chen, et al. Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity. Biochemical and Biophysical Research Communications, 2014, 454: 537-542.
[6]. Christopher J. Carter. Identification of novel retinoid receptors and their roles in vertebrate and invertebrate nervous systems [D]. St. Catharines: Brock University, 2011.
Physical Appearance | Yellow solid |
Storage | Store at RT |
M.Wt | 353.41 |
Cas No. | 870773-76-5 |
Formula | C17H20FNO4S |
Solubility | <35.34mg/ml in DMSO; <35.34mg/ml in ethanol |
Chemical Name | 4-(4-(2-butoxyethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid |
SDF | Download SDF |
Canonical SMILES | FC1=CC(C2=NC(OCCOCCCC)=C(C)S2)=CC=C1C(O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |