AC 187
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
胰岛淀粉样多肽是一种含有37个氨基酸的多肽,在胰腺β细胞中与胰岛素共同分泌.养分刺激引起胰淀素的血浆浓度增加.AC187是有效的胰淀素拮抗剂.
体外实验:AC187有效地竞争结合大鼠胰淀素的高亲和力结合位点,如大鼠伏隔核膜,这对于开发一系列选择性配体具有重要作用,包括AC187.胰淀素在该位点的Kd值为28 pM,AC187的Ki值为79 pM.AC187与胰淀素竞争结合,具有相对选择性,可代替伏隔核膜上的胰淀素,具有超过400倍的效力[1].
在体实验:在完整的动物中,AC187能够抑制外源胰淀素的代谢应答.在麻醉大鼠中,AC187的注入不影响乳酸水平,而大鼠胰淀素抑制90％以上的乳酸增量.其它实验表明,高剂量的胰淀素克服了AC187诱导的胰淀素阻断作用,表明其具有竞争性拮抗作用[1].
临床试验:到目前为止,AC187还处于临床前开发阶段.
参考文献：
[1] Young AA, Gedulin B, Gaeta LS, Prickett KS, Beaumont K, Larson E, Rink TJ. Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. Evidence for a metabolic role of endogenous amylin. FEBS Lett. 1994 May 2;343(3):237-41.
| Physical Appearance | White lyophilised solid |
| Storage | Desiccate at -20°C |
| M.Wt | 2890.25 |
| Cas No. | 151804-77-2 |
| Formula | C127H205N37O40 |
| Solubility | Soluble to 1 mg/ml in H2O |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
