A 438079 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
A 438079盐酸盐是一种选择性的P2X7受体拮抗剂，在大鼠和人体内的IC50值分别为100和300 nM[1]。
A 438079是初始化合物5四唑的衍生物，其被选为新型P2X7受体拮抗剂。在表达重组人P2X7的人类1321N1星形细胞瘤细胞中，A 438079用药可抑制Ca2+流，pIC50值为6.9。在孔形成试验中，A 438079阻滞人类THP-1细胞的孔形成，且阻止细胞摄取有机染料YO-PRO。此外，在脊髓神经结扎模型中，A 438079给药可减少由纤毛机械刺激针诱发的神经性疼痛，ED50值为76 μM/kg [2]。
参考文献：
1. Nelson D W, Gregg R J, Kort M E, et al. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. Journal of medicinal chemistry, 2006, 49(12): 3659-3666.
2. Donnelly-Roberts D L, Jarvis M F. Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. British journal of pharmacology, 2007, 151(5): 571-579.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 342.61 |
| Cas No. | 899431-18-6 |
| Formula | C13H10Cl3N5 |
| Solubility | ≥34.3 mg/mL in DMSO; ≥49.8 mg/mL in EtOH with gentle warming and ultrasonic; ≥94 mg/mL in H2O |
| Chemical Name | 3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
