A 419259 trihydrochloride
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
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Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
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Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
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Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
A 419259 trihydrochloride是口服有效的Lck抑制剂,其IC50值为15 nM[1].
Lck属于src家族酪氨酸激酶.抑制Lck可以防止T细胞活化,因而用于治疗T-细胞相关疾病,如自身免疫与炎症性疾病.A 419259 trihydrochloride有效地抑制重组lck(64 ~ 509),其IC50值为15 nM.A 419259 trihydrochloride也是一种选择性抑制剂,对其它激酶无效,包括cMet\IGFR\PKC和PDGFR.在Jurkat细胞中,A 419259 trihydrochloride抑制IL-2生成,其IC50值为25 nM.此外,在小鼠中,A 419259 trihydrochloride抑制IL-2生成,其ED50值为2.5 mg/kg.A 419259 trihydrochloride还作用于抗原特异性T细胞免疫应答.体内试验表明,A 419259 trihydrochloride在给药初期可以抑制IFN-γ生成[1].
参考文献:
[1] Calderwood D J, Johnston D N, Munschauer R, et al. Pyrrolo [2, 3-d] pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck. Bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 592 |
Cas No. | 1435934-25-0 |
Formula | C29H37Cl3N6O |
Solubility | Soluble in DMSO |
Chemical Name | 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride |
SDF | Download SDF |
Canonical SMILES | CN1CCN([C@@]2([H])CC[C@@](N3C=C(C(C3=NC=N4)=C4N)C5=CC=C(OC6=CC=CC=C6)C=C5)([H])CC2)CC1.Cl.Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
化学结构
![A 419259 trihydrochloride](http://www.apexbt.com//media/diy/images/struct/B1301.png)