DiscoveryProbe™ Protease Inhibitor Library
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
- 1. Sebastjan Kralj, Marko Jukič, et al. "Commercial SARS-CoV-2 Targeted, Protease Inhibitor Focused and Protein-Protein Interaction Inhibitor Focused Molecular Libraries for Virtual Screening and Drug Design." Int J Mol Sci. 2021 Dec 30;23(1):393. PMID: 35008818
- 2. Tenghua Wang, Wenxiu Ye, et al. "Protease Inhibitor-Dependent Inhibition of Light-Induced Stomatal Opening." Front Plant Sci. 2021 Sep 10;12:735328. PMID: 34567048
- 3. Huang L, Li L, et al. "Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment." Sci Rep. 2019 Jan 22;9(1):301. PMID: 30670786
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A2576 | E-64 | Cysteine protease inhibitor,irriversible | Cathepsin | 66701-25-5 | CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O | |
| A2606 | Epoxomicin | Proteasome inhibitor | Proteasome | 134381-21-8 | CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C | |
| A4018 | YO-01027 (Dibenzazepine, DBZ) | γ-secretase inhibitor | Gamma Secretase | 209984-56-5 | CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F | |
| A4054 | 17-AAG (KOS953) | Hsp90 inhibitor | HSP | 75747-14-7 | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC | |
| A8200 | DAPT (GSI-IX) | γ-secretase inhibitor,potent and specific | Amyloid β | 208255-80-5 | CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F | |
| A8203 | Ritonavir | HIV protease inhibitor | HIV Protease | 155213-67-5 | CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O | |
| A8206 | Darunavir | HIV-1 protease inhibitor | HIV Protease | 635728-49-3 | CCO.CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N | |
| A8239 | CA-074 Me | Cathepsin B inhibitor | Cathepsin | 147859-80-1 | CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC | |
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下载 APExBIO化合物库使用说明 下载 DiscoveryProbe™ Protease Inhibitor Library（SDF & XLSX） |
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| Form | Pre-dissolved DMSO solutions | Stability | Solution: -20°C for 12 months, -80°C for 24 months |
| Packaging | 96-well DeepWell format with peelable foil seal and EVA cap (100 μL/well, 10 mM DMSO). 96-well rack with Matrix 2D Barcoded ScrewTop Storage tubes (250 μL or 100 μL/well, 10 mM DMSO). |
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| Shipping Condition | Evaluation sample solution: ship with blue ice All other available size: ship with RT, or blue ice upon request |
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-- Available in stock with overnight delivery and free shipping over $500.
-- Cost-effective and competitive price to save your budget.
-- Potent, selective and cell-permeable in inhibiting or activating target molecules.
-- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
-- Detailed files describing potency, selectivity and applications etc.
-- Supported by published data from top peer-reviewed journals.
-- Guaranteed high quality with NMR and HPLC validation.
